What are ADYNOVATE and ADVATE® [Antihemophilic Factor (Recombinant)]?

ADYNOVATE and ADVATE are injectable medicines that are used to help treat and control bleeding in children and adults with hemophilia A. ADYNOVATE and ADVATE are not used to treat von Willebrand disease.1,2

Dedicated to advancing care for people with hemophilia A

ADYNOVATE is built on the ADVATE molecule, a proven treatment in hemophilia A patients.1,2

There have been many advancements in the treatment of hemophilia A. Below are a few of Takeda's milestones that demonstrate its commitment to the hemophilia A community:

  • The 1st genetically manufactured Factor VIII3
  • ADVATE, the 1st recombinant factor VIII made without added human or animal proteins, is approved1,4
  • ADYNOVATE, built on the same molecule as ADVATE but with a longer half-life, is approved1
  • myPKFiT®, the first and only FDA-approved mobile app for patients with severe hemophilia A is approved for use with ADYNOVATE patients 12 years and older and with a weight of 29 kg and greater4

myPKFiT is not indicated for the treatment of von Willebrand disease and should not be used for patients who have developed neutralizing antibody to FVIII products. myPKFiT is Rx only. For safe and proper use of the myPKFiT mobile app please refer to complete instructions for use in the User Manual.

Please see the full Intended Use Statement for the myPKFiT mobile app below.

SELECTED IMPORTANT RISK INFORMATION

What are possible side effects of ADYNOVATE and ADVATE?

  • ADYNOVATE: The common side effects of ADYNOVATE are headache and nausea. These are not all the possible side effects with ADYNOVATE. Tell your HCP about any side effects that bother you or do not go away.
  • ADVATE: Side effects that have been reported with ADVATE include: cough, headache, joint swelling/aching, sore throat, fever, itching, unusual taste, dizziness, hematoma, abdominal pain, hot flashes, swelling of legs, diarrhea, chills, runny nose/congestion, nausea/vomiting, sweating, and rash. Tell your HCP about any side effects that bother you or do not go away or if your bleeding does not stop after taking ADVATE.

See Detailed Important Risk Information below.

In the hemophilia A community, no two patients are the same

When finding a treatment for hemophilia A, you and your healthcare provider should consider your individual needs.5 There are many characteristics that make you different.5,6

Icon of man running on a treadmill.
  • Your physical activity and lifestyle
  • Your bleeding phenotype
  • Your pharmacokinetic (PK) profile
Icon of calendar.
  • The frequency of your medication and infusion dose
  • How well you stick to your prescribed dosing schedule
  • Your pharmacokinetic (PK) profile
Icon of scale.
  • Your personal goals
  • Other relevant facts about you (e.g., age, weight)
While living with hemophilia A will always be a part of your reality, both the welcome and unwelcome moments, you need treatment options that can help navigate the complexities of real life with hemophilia A.

Light bulb Icon.What is a bleeding phenotype?

A patient's bleeding phenotype is a collection of his/her bleed history including bleeding disorder type and severity, annual bleed frequency, and overall joint health.7

Light bulb Icon.What is PK?

Pharmacokinetics (or "PK") is the science of how a drug is used up in the body.3 A PK Profile for an individual person helps determine how quickly or slowly a person's body breaks down their treatment.8

Collage of man living everyday life.

Treating on-demand? Living an active lifestyle?
Love to travel?

Talk to your doctor about whether personalized treatment with ADYNOVATE may be right for you.

SELECTED IMPORTANT RISK INFORMATION

Who should not use ADYNOVATE:

Do not use ADYNOVATE if you:

  • Are allergic to mice or hamster protein
  • Are allergic to any ingredients in ADYNOVATE or ADVATE [Antihemophilic Factor (Recombinant)]

Tell your HCP if you are pregnant or breastfeeding because ADYNOVATE may not be right for you.

See Detailed Important Risk Information below.

Stories from people like you

Learn what real people with hemophilia A are saying about treatment with ADYNOVATE

See stories
ADYNOVATE Safety

Learn about the safety information and side effects of treatment with ADYNOVATE

Get safety data